Repeated rat-forced swim test: Reducing the number of animals to evaluate gradual effects of antidepressants
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چکیده
منابع مشابه
Repeated rat-forced swim test: Reducing the number of animals to evaluate gradual effects of antidepressants
The forced swim test (FST) is a pre-clinical test to short and long term treatment with antidepressant drugs (ADT), which requires between-subject designs. Herein a modified protocol of the FST using within-subject design (repeated rat-FST) was evaluated. Male Wistar rats were submitted to 15 min of swimming (Day 1: pretest) followed by three subsequent 5 min-swimming tests one week apart (Day ...
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Repeated forced swimming test (rFST) may detect gradual effects of antidepressants in adult rats. Antidepressants, as enrichment, affected behavior and neurogenesis in rats. However, the influence of enrichment on behavioral and neurogenic effects of antidepressants is unknown. Here, effects of antidepressants on rFST and hippocampal neurogenesis were investigated in rats under enriched conditi...
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The forced swim test is a rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental manipulations that are aimed at rendering or preventing depressive-like states. Mice are placed in an inescapable transparent tank that is filled with water and their escape related mobility behavior is measured. The forced swim test is straigh...
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ژورنال
عنوان ژورنال: Journal of Neuroscience Methods
سال: 2011
ISSN: 0165-0270
DOI: 10.1016/j.jneumeth.2010.12.015